Neurons use protein condensates to read genes over 100,000 base pairs long

Researchers from Ehime University discovered that neurons use protein condensates formed by SFPQ to manage extra-long genes spanning over 100,000 base pairs. These condensate structures act as organizational hubs, integrating transcription, splicing, and chromatin regulation. When condensate architecture breaks down, gene expression falters, potentially linking this mechanism to neurodevelopmental disorders like autism spectrum disorder.

SFPQ condensates act as integrated hubs, coordinating transcription, splicing, and chromatin dynamics simultaneously.